How much hormone helps improve IVF success?
fertility is the impossibility to conceive after one year of regular attempts in the absence of a contraceptive.
Usually infertility is a complex issue because causes are varied and can combine masculine and feminine disorders requiring an individualized study of each case.
However, in 30% of all occurrences there is a documented feminine cause. For most women emotional consequences of not getting a pregnancy after some time are usually taxing and devastating.
In industrialized countries, one of six couples is estimated to be infertile.
WHO recognizes infertility as a global public health issue and reproductive medicine as an appropriate strategy to address it.
Moreover, infertility in women has been ranked the 5th highest serious disability in their fertile period.
Social changes introducing women in labor markets have postponed maternity to later stages.
From the time a woman enters her 30s, fertility decreases and abortion risk increases, becoming one of the main issues that affects pregnancy rates nowadays.
Besides maternal age, there are many other factors that can determine feminine infertility like obesity, anatomical lesions, ovulation disruption, endocrine disorders, previous surgeries, infections or chemotherapy treatments, among others.
Medical interventions, generally called assisted reproduction techniques (ART), include all the clinical approaches to overcome an infertile diagnosis. Since natural ovulation (egg release from the ovary) only produces one egg or oocyte every month, those interventions usually start off by stimulating ovaries to increase the opportunities.
Female hormones that naturally modulate ovulation are called gonadotropins.
Infertility treatments use a high dose of synthetic gonadotropins to induce a multiple ovulation and collect several oocytes from women.
Then fertilization procedure of these oocytes will be performed inside the body (artificial insemination) or in the lab (in vitrofertilization, IVF).
If the approach is appropriated and the intervention is accurate, prospects for pregnancy can improve in a high percentage, sometimes beyond 50%.
As a general rule, the more oocytes retrieved the better chances to get a viable embryo after fertilization procedure.
However, results actually depend on a balance between the number and the quality of oocytes to be fertilized and end up in pregnancy.
Gonadotropins are usually administered in a dose according to patient features.
More than 35 years old, a high body mass index (BMI), and additional infertility disorders are common predictors of poor response (bad egg recovery rate).
In those cases, physicians tend to increase the hormones to improve the prospects.
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